Ceftisyl Hydro suspension for injections
- Broad-spectrum antibacterial effect.
- Milk can be used without restriction after the drug administration.
Chemical composition and pharmacological properties1 ml of Ceftisyl Hydro contains ceftiofur hydrochloride - 50 mg (as an active ingredient) and excipients.
It is a third generation cephalosporin antibacterial drug.
Ceftiofur hydrochloride (a component of the drug) has broad-spectrum antibacterial effect on gram-positive and gram-negative bacteria (such as Pasteurella spp., Haemophilus spp., Escherichia coli, Salmonella spp., Staphylococcus spp., Streptococcus spp., Fusobacterium necrophorum, Arcanobacterium pyogenes including beta-lactamase producing strains).
Peak blood concentration of ceftiofur and its metabolites is obtained within 0.5-2 hours after administration. It remains at therapeutic level for at least 24 hours. The antibiotic is mainly excreted in urine (>55%) and partially in feces. Depending on type, age and method of administration, elimination half-life is 10-19 hours.
IndicationsUse Ceftisyl Hydro to treat cattle and pigs with respiratory diseases, interdigital necrobacillosis, acute puerperal endometritis and other primary and secondary bacterial infections, agents of which are susceptible to ceftiofur.
ContraindicationsIncreased individual sensitivity to beta-lactame antibiotics.
Do not use in combination with tetracyclines and levomycetin (due to decrease in drug bactericidal activity), aminoglycosides, furosemide and ethacrynic acid (due to potential increase in nephrotoxic effect).
AdministrationParenteral administration once a day. Doses are listed below:
• pigs - intramusculary, 1 ml per 16 kg of body weight (3 mg of ceftiofur per 1 kg of body weight) within 3-5 days;
• cattle - subcutaneously or intramusculary, 1 ml per 50 kg of body weight (1 mg of ceftiofur per 1 kg of body weight) within 3-5 days (respiratory diseases), 3 days (acute interdigital necrobacillosis) or 5 days (acute puerperal endometritis within first 10 days after delivery).
•Before every use carefully shake a bottle with the drug.
Waiting periodCattle and pigs are allowed to be slaughtered for meat not earlier than 8 and 5 days, respectively, after the last drug administration. Milk of milking cows received during drug administration period is esculent without restriction.
Adverse eventsOverdose: potential dysorexia and inflammation of injection site.
StorageStore in closed original package at 2-30°С. Protect from direct sunlight and moisture.
Shelf life is 2 years from manufacturing date and 28 days from the first bottle opening.